Are you the eldest man in the home? If so I would perform ganapati homam to cleanse the structure then immediately with a sincere heart conduct shodasa upachara puja to the Kuladeivam. During the third offering (aasana) not only mean the image and shrine but rather the entire home and hearts of every family member for the perpetuity of your lineage. There is no sin of the father the son cannot help mend. To carry your families name is to carry their karma thus some would argue that this is your responsibility.
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Roman
PS All that said I completely agree with sri prasad1 and renukaji! Remember, god doesn't NEED the puja however your family might need the reconnection to god and that is what the puja brings to the heart, body, and soul. Our outward devotion reinforces our inner commitments to ourselves, god, family, and community.