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Indian scientist develops potential non-insulin diabetes drugs

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New York:

Indian scientist develops potential non-insulin diabetes drugs

A young Indian scientist has developed a potential non-insulin drug candidate for diabetic patients that can help eliminate the risk of low-blood glucose shock in case of an insulin overdose.

Arnab De, a PhD in Microbiology and Immunology from Columbia University in New York, has developed the non-insulin drug candidate in collaboration with Richard Di Marchi of Indiana

Patients use insulin to keep their sugar levels in check,an overdose of insulin can lead to low blood-glucose (hypoglycemia), which may cause diabetic-coma and be life-threatening. Insulin treatment has also been reported to cause weight-gain that may exacerbate a diabetic condition, De told PTI.

"We find that there is a peptide hormone in the gut called GLP1 that increases the secretion of insulin only when the blood glucose is high. This effectively eliminates the risk of hypoglycemic shock. Another advantage is that GLP1 administration has been found to stimulate weight-loss.The hormone offers the promise of revolutionizing the
treatment of Type II diabetes and reduce obesity," he said.

Regarding the clinical trial of the new drug, De said that GLP-1 has an extremely short half-life of two minutes and this instability has impeded its effective use in patients. As per a study published in the journal Peptide Science, De and Di Marchi "envisioned a prodrug of GLP as a means to extend the duration of action" and their research resulted in several range of options for prolonging peptide action to once-a-day and once-a-week formulations.

"Needless to say, this will be very helpful for patients as we might have a formulation that needs to be taken only once a week as opposed to after every meal" De said. Subho Mozumdar, faculty member ,University of Delhi said that the development of a GLP-1 based pro-drug represents a patient-friendly, diabetic therapeutic. "It is a remarkable breakthrough which might also help to defend against obesity and perhaps against Alzheimer's disease too. There is a huge market for such a therapeutic in India given the growing number of patients," said Mozumdar.

As per estimates by The International Diabetes Federation, around one in five individuals suffer from some form of obesity.These individuals are three times more prone to heart
attacks or stroke and five times more likely to develop adult-onset of diabetes vis-a-vis individuals without the syndrome.

Indiana University Research and Technology Corporation (IURTC) has applied for patents internationally on these pro-drugs in the world-wide market.De has been conferred the prestigious Young Investigator's Award by American Peptide Society."I hope going forward this drug essentially helps people.That is when the years of hard work and research will pay
off," he added.

Indian scientist develops potential non-insulin diabetes drugs | NDTV.com
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